LRF OCEHL journal article on insulin resistance
Insulin resistance is associated with mammary mitochondrial dysfunction at the onset of human lactation
Xin Meng, Taha Elajnaf, Hussam Rostom, Michelle Ma, Annalee Furst, Bryony R. Davies, Isabella R. Honess, Gaurav Pandey, Isadora C. Furigo, Craig L. Doig, Jayne F. Martin, Carli, Rajesh V. Thakker, Lars Bode, Kelsey E. Johnson, Fadil M. Hannan
LRF-OCEHL have published a paper showing how insulin resistance (a clinical condition affecting around 40% of women of reproductive age) may impact lactation.
The team have found that insulin resistance impairs the energy producing units (known as “mitochondria") of mammary cells.
This image shows that insulin administered to mammary cells in the lab increased the formation of new mitochondria, whilst excess insulin caused the mitochondria to fragment.
This work highlights a role for insulin in promoting energy production to support lactation.
